The Carabeo Lab

• Pokorzynski ND, Brinkworth AB, Carabeo RA (2019) A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis. Elife. pii: e42295. doi: 10.7554/eLife.42295.

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• Tietzel I, Quayle AJ, Carabeo RA (2019) Alternatively activated macrophages are host cells for Chlamydia trachomatis and reverse anti-chlamydial classically activated macrophages. Front. Microbiol. doi: 10.3389/fmicb.2019.00919.

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• Brinkworth AB, Wildung MR, Carabeo RA. (2018) Genomewide transcriptional responses of iron-starved Chlamydia trachomatis reveal prioritization of metabolic precursor synthesis over protein translation. mSystems. doi: 10.1128/mSystems.00184-17

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• Nogueira AT, Braun KM, and Carabeo RA. (2017) Characterization of the growth of Chlamydia trachomatis in in vitro-generated stratified epithelium. Front Cell Infect Microbiol. doi: 10.3389/fcimb.2017.00438.

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• Pokorzynski ND, Thompson CC, and Carabeo RA. (2017) Ironing out the unconventional mechanisms of iron acquisition and gene regulation in Chlamydia. Front Cell Infect Microbiol. doi: 10.3389/fcimb.2017.00394.

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• Nogueira AT, Pedrosa AT, Carabeo RA. (2016) Manipulation of the Host Cell Cytoskeleton by Chlamydia. Curr Top Microbiol Immunol. PMID: 27197645

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• Thwaites TR, Pedrosa AT, Peacock TP, Carabeo RA. (2015) Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane. Front Cell Infect Microbiol. 5:88. doi: 10.3389/fcimb.2015.00088.

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• Thwaites, TR, Nogueira AT, Campeotto I, Silva AP, Grieshaber SS, and Carabeo RA. (2014) The Chlamydia effector TarP mimics the mammalian LD motif of paxillin to subvert the focal adhesion kinase during invasion. J. Biol. Chem. 289:30426-42.

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• Thompson CC, Nicod S, Malcolm D, Grieshaber SS, and Carabeo RA. (2012) An iron-dependent transcriptional regulator is generated from cleavage of the YtgC permease in Chlamydia trachomatis. Proc. Nat. Acad. Sci. U.S.A. 109:10546-51.

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• Brinkworth AJ, Malcolm DS, Pedrosa AT, Roguska K, Shahbazian S, Graham JE, Hayward, RD, and Carabeo RA. (2011) Chlamydia trachomatis Slc1 is a type III secretion chaperone that enhances the translocation of its invasion effector substrate TARP. Mol Microbiol. 82:131-44.

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• Fields KA, Heinzen, RA, and Carabeo RA. (2011) The obligate intracellular lifestyle. Front Microbiol. 2:99.

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• Thompson CC, and Carabeo RA. (2011) An optimal method of iron starvation of the obligate intracellular pathogen, Chlamydia trachomatis. Front. Microbio. 2:20. doi:10.3389/fmicb.2011.00020.

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• Ouellette SP, Dorsey F, Moshiach S, Cleveland J, and Carabeo RA. (2011) Chlamydia Species-Dependent Differences in the Growth Requirement for Lysosomes. PLoS ONE. 10.1371/journal.pone.0016783.

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• Carabeo RA. (2011) Bacterial subversion of host actin dynamics at the plasma membrane. Cell Microbiol. doi:10.1111/j.1462-5822.2011.01651.x

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• Ouellette SP, and Carabeo RA. (2010) A Functional Slow Recycling Pathway of Transferrin is Essential for Chlamydial Intracellular Growth. Front. Microbiol. doi: 10.3389/fmicb.2010.00112.

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• Tietzel I, El-Haibi C, and Carabeo RA. (2009) The Human Guanylate Binding Proteins Potentiate the Anti-Chlamydial Effects of Interferon-g. PLoS ONE 4(8): e6499.

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• Lane BJ, Mutchler C, and Carabeo RA. (2008) Chlamydial Invasion Involves TARP binding of Two distinct Rac-specific Guanine Nucleotide Exchange Factors.  PLOS Pathogens 4:e1000014.

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• Molmeret M, Santic M, Asare R, Carabeo RA, Kwaik YA. (2007) Rapid Escape of the dot/icm Mutants of Legionella pneumophila Into the Cytosol of Mammalian and Protozoan Cells. Infect. Immun. 75:3290-3304.

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• Carabeo RA, Dooley CA, Grieshaber SS, and Hackstadt T.  (2007) Rac Interacts with Abi-1 and WAVE2 to Promote an Arp2/3-dependent Actin Recruitment During Chlamydial Invasion.  Cell. Microbiol., 9:2278-2288.

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• Clifton DR, Dooley CA, Grieshaber SS, Fields KA, Carabeo RA, Hackstadt T.  (2005).  Tyrosine Phosphorylation of the Chlamydia Effector Protein Tarp is Species-Specific and Not Required for Recruitment of Actin.  Infect. Immun., 73:3860-3868.

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• Clifton DR, Fields KA, Grieshaber SS, Dooley CA, Fischer ER, Mead DJ, Carabeo RA, Hackstadt T.  (2004).  A Chlamydial Type III Translocated Protein is Tyrosine Phosphorylated at the Site of Entry and Associated with Recruitment of Actin.  Proc. Nat. Acad. Sci. U.S.A., 101:10166-10177.

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• Carabeo RA, Grieshaber SS, Dooley CA, Hasenkrug A, and Hackstadt T. (2004). Requirement for the Rac GTPase in Chlamydia trachomatis Invasion of Non-phagocytic Cells.  Traffic, 5:418-425.

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• Carabeo RA, Mead DJ, Hackstadt T. (2003). Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion.  Proc. Natl. Acad. Sci. USA. 100:6771-6.

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• Carabeo RA, Grieshaber SS, Fischer E, Hackstadt T. (2002). Chlamydia trachomatis induces remodeling of the actin cytoskeleton during attachment and entry into HeLa cells. Infect. Immun. 70:3793-803.

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• Carabeo RA, Hackstadt T. (2001). Isolation and characterization of a mutant Chinese hamster ovary cell line that is resistant to Chlamydia trachomatis infection at a novel step in the attachment process.  Infect. Immun. 69:5899-904.